Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes.

TitleRisk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes.
Publication TypeJournal Article
Year of Publication2012
AuthorsJulià, Antonio, Tortosa Raül, Hernanz José Manuel, Cañete Juan D., Fonseca Eduardo, Ferrándiz Carlos, Unamuno Pablo, Puig Lluís, Fernández-Sueiro José Luís, Sanmartí Raimon, Rodríguez Jesús, Gratacós Jordi, Dauden Esteban, Sánchez-Carazo José Luís, López-Estebaranz José Luís, Moreno-Ramírez David, Queiró Rubén, Montilla Carlos, Torre-Alonso Juan Carlos, Pérez-Venegas José Javier, Vanaclocha Francisco, Herrera Enrique, Muñoz-Fernández Santiago, González Carlos, Roig Daniel, Erra Alba, Acosta Isabel, Fernández-Nebro Antonio, Zarco Pedro, Alonso Arnald, López-Lasanta María, García-Montero Andrés, Gelpí Josep-Lluis, Absher Devin, and Marsal Sara
JournalHum Mol Genet
Volume21
Pagination4549-57
Date Published2012 Oct 15
ISSN1460-2083
KeywordsAdaptor Proteins, Alleles, Aminopeptidases, Case-Control Studies, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Genotype, HLA-C Antigens, Humans, Interleukin 1 Receptor Antagonist Protein, Male, Phenotype, Psoriasis, Skin, Vesicular Transport
Abstract

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Recent genome-wide association studies (GWASs) have identified >20 new loci associated with the susceptibility to psoriasis vulgaris (PsV) risk. We investigated the association of PsV and its main clinical subphenotypes with 32 loci having previous genome-wide evidence of association with PsV (P

DOI10.1093/hmg/dds295