Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions.
|Title||Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions.|
|Publication Type||Journal Article|
|Year of Publication||2006|
|Authors||J Goñi, Ramon, Vaquerizas Juan Manuel, Dopazo Joaquin, and Orozco Modesto|
|Keywords||Animals, Base Sequence, Computational Biology, DNA, Genetic, Genome, Human, Humans, Mice, Nucleic Acid, Nucleic Acid Conformation, Nucleotides, Oligonucleotides, Promoter Regions, Regulatory Sequences, Transcription Factors|
BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions.
RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome.
CONCLUSION: Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region.