A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.

TitleA genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
Publication TypeJournal Article
Year of Publication2014
AuthorsJulià, Antonio, Domènech Eugeni, Chaparro María, García-Sánchez Valle, Gomollón Fernando, Panés Julián, Mañosa Míriam, de Acosta Manuel Barreiro-, Gutiérrez Ana, Garcia-Planella Esther, Aguas Mariam, Muñoz Fernando, Esteve Maria, Mendoza Juan L., Vera Maribel, Márquez Lucía, Tortosa Raül, López-Lasanta María, Alonso Arnald, Gelpí Josep-Lluis, García-Montero Andres C., Bertranpetit Jaume, Absher Devin, Myers Richard M., Gisbert Javier P., and Marsal Sara
JournalHum Mol Genet
Volume23
Pagination6927-34
Date Published2014 Dec 20
ISSN1460-2083
KeywordsAdult, Case-Control Studies, Chromosomes, Colitis, DNA, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Human, Humans, Intergenic, Male, Membrane Glycoproteins, Middle Aged, Odds Ratio, Pair 6, Polymorphism, Single Nucleotide, Ulcerative
Abstract

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The genetic analysis of ulcerative colitis (UC) has provided new insights into the etiology of this prevalent inflammatory bowel disease. However, most of the heritability of UC (>70%) has still not been characterized. To identify new risk loci for UC we have performed the first genome-wide association study (GWAS) in a Southern European population and undertaken a meta-analysis study combining the newly genotyped 825 UC patients and 1525 healthy controls from Spain with the six previously published GWAS comprising 6687 cases and 19 718 controls from Northern-European ancestry. We identified a novel locus with genome-wide significance at 6q22.1 [rs2858829
DOI10.1093/hmg/ddu398