FlexServ: an integrated tool for the analysis of protein flexibility.
Title | FlexServ: an integrated tool for the analysis of protein flexibility. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Camps, Jordi, Carrillo Oliver, Emperador Agustí, Orellana Laura, Hospital Adam, Rueda Manuel, Cicin-Sain Damjan, D’Abramo Marco, Gelpí Josep-Lluis, and Orozco Modesto |
Journal | Bioinformatics |
Volume | 25 |
Pagination | 1709-10 |
Date Published | 2009 Jul 1 |
ISSN | 1367-4811 |
Keywords | Computational Biology, Databases, Internet, Protein, Protein Conformation, Proteins, Sequence Analysis, Software |
Abstract | SUMMARY: FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann’s indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics. AVAILABILITY: https://mmb.pcb.ub.es/FlexServ; https://www.inab.org |
DOI | 10.1093/bioinformatics/btp304 |