Triplex formation using oligonucleotide clamps carrying 8-aminopurines.

TitleTriplex formation using oligonucleotide clamps carrying 8-aminopurines.
Publication TypeJournal Article
Year of Publication2007
AuthorsAviñó, Anna, Grimau Marta G., Alvira Margarita, Eritja Ramon, Gargallo Raimundo, Orozco Modesto, and González Carlos
JournalNucleosides Nucleotides Nucleic Acids
Date Published2007
KeywordsBacterial, Caulimovirus, DNA, Drug Design, Drug Stability, Genetic, Hydrogen Bonding, Listeria, Molecular Probes, Nucleic Acid Conformation, Oligonucleotides, Promoter Regions, Purine Nucleotides, RNA, Viral

The synthesis and properties of triplex-forming DNA clamps carrying 8-aminopurines are described. The stability of triple helices is enhanced by replacing purine bases with 8-aminopurine residues. These enhanced binding properties are used for the specific capture of polypyrimidine RNA/DNA sequences of interest.