Triplex formation using oligonucleotide clamps carrying 8-aminopurines.
| Title | Triplex formation using oligonucleotide clamps carrying 8-aminopurines. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Aviñó, Anna, Grimau Marta G., Alvira Margarita, Eritja Ramon, Gargallo Raimundo, Orozco Modesto, and González Carlos |
| Journal | Nucleosides Nucleotides Nucleic Acids |
| Volume | 26 |
| Pagination | 979-83 |
| Date Published | 2007 |
| ISSN | 1525-7770 |
| Keywords | Bacterial, Caulimovirus, DNA, Drug Design, Drug Stability, Genetic, Hydrogen Bonding, Listeria, Molecular Probes, Nucleic Acid Conformation, Oligonucleotides, Promoter Regions, Purine Nucleotides, RNA, Viral |
| Abstract | The synthesis and properties of triplex-forming DNA clamps carrying 8-aminopurines are described. The stability of triple helices is enhanced by replacing purine bases with 8-aminopurine residues. These enhanced binding properties are used for the specific capture of polypyrimidine RNA/DNA sequences of interest. |
| DOI | 10.1080/15257770701508398 |