Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions.

TitleExploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions.
Publication TypeJournal Article
Year of Publication2006
AuthorsJ Goñi, Ramon, Vaquerizas Juan Manuel, Dopazo Joaquin, and Orozco Modesto
JournalBMC Genomics
Volume7
Pagination63
Date Published2006
ISSN1471-2164
KeywordsAnimals, Base Sequence, Computational Biology, DNA, Genetic, Genome, Human, Humans, Mice, Nucleic Acid, Nucleic Acid Conformation, Nucleotides, Oligonucleotides, Promoter Regions, Regulatory Sequences, Transcription Factors
Abstract

BACKGROUND: DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions.

RESULTS: Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome.

CONCLUSION: Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region.
DOI10.1186/1471-2164-7-63