Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
|Title||Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||da Rosa, Gabriela, Grille Leandro, Calzada Victoria, Ahmad Katya, Arcon Juan Pablo, Battistini Federica, Bayarri Genis, Bishop Thomas, Carloni Paolo, III Thomas Cheatham, Collepardo-Guevara Rosana, Czub Jacek, Espinosa Jorge R., Galindo-Murillo Rodrigo, Harris Sarah A., Hospital Adam, Laughton Charles, Maddocks John H., Noy Agnes, Orozco Modesto, Pasi Marco, Pérez Alberto, Petkevičiūtė-Gerlach Daiva, Sharma Rahul, Sun Ran, and Dans Pablo D.|
The structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA to recognize ligands and consequently on its functionality. In this sense, the knowledge obtained from the sequence-dependent structural properties of B-DNA has always been thought crucial to rationalize how ligands and, most notably, proteins recognize B-DNA and modulate its activity, i.e. the structural basis of gene regulation. Honouring the anniversary of the first high-resolution X-ray structure of a B-DNA molecule, in this contribution, we present the most important discoveries of the last 40 years on the sequence-dependent structural and dynamical properties of B-DNA, from the early beginnings to the current frontiers in the field.
|Short Title||Biophysical Reviews|